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[Read: San Francisco 49ers Fear QB Jimmy Garoppolo Has a Torn A.C.L.]

At the helm of Kansas City’s video game-like offense, Mahomes used all of his options on offense, completing passes to nine different receivers. But after running up a 35-7 lead in the second quarter, Mahomes had to watch as his team’s defense left the door open for a potential 49ers comeback — one short-circuited by an injury to San Francisco’s Jimmy Garoppolo — proving that Kansas City’s margin for error on offense, barring significant changes, is effectively zero.Sponsored: Gambar Koala

Mahomes’s 13 touchdown passes through the first three weeks of the season broke the previous record of 12, which was set by Peyton Manning in 2013.

Most of the damage came with Mahomes throwing to his favorite target, Travis Kelce, who had eight catches for 114 yards, but the touchdowns were spread around to Sammy Watkins, Demetrius Harris and Chris Conley. Mahomes finished the game having completed 24 of 38 passes for 314 yards, his third consecutive week of 250 or more passing yards and three or more touchdowns.

Mahomes thought they could have done more.

“I know that we’re going to keep getting better,” he said after the game. “We’re still leaving a lot out there.”

Kansas City only had 77 rushing yards, but Kareem Hunt scored two touchdowns.

Despite Kansas City’s early 28-point lead at home, and San Francisco finishing the game with an astounding 147 yards of penalties, Garoppolo, with a great deal of help from the 49ers running backs, made a game of it.

San Francisco reeled off 17 unanswered points, narrowing the deficit to 11 at one point, and Garoppolo had the ball in the red zone late in the fourth quarter. But with a chance of getting the game within a single score, a hard hit on the sideline forced Garoppolo out of the game with an injury to his left leg.

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